It wasn't until Amy was over a year old that we realized that she might be allergic to nickel. I bought some of those pajamas that have the top and the bottom snap together. She would wake up with round marks on her torso the size of the snap. The doctor was quickly able to identify a nickel allergy when I mentioned it.
It was fairly easy to keep the allergy in control until Amy started wearing jeans with snaps, adding belts to outfits, and having her ears pierced. She has had to learn to add a coat of nail polish to the back side of the snap (and that doesn't completely work), to wear unders that cover where the snap might contact her skin, and invest in good quality earrings. She has to be careful with all types of jewelry as it contacts her skin.
The latest issue that we have had to deal with was an allergy to her BRACES, of all things. The rash started almost immediately around her mouth and has continued since. She started taking benadryl at night and could also try hydrocortisone cream (but hasn't yet). We were hoping to have the braces off in May, but that is looking iffy now. Being allergic to her braces is extremely rare, and because of the cost involved, you can't just take them off and try something different. I told her she ought to feel special. She wasn't buying it.